Evaluation of the Hematologic and Biochemical Profile of Patients With Chronic Kidney Disease Undergoing Renal Replacement Therapy.

Abstract

This study aimed to describe the profile of the main hematologic and biochemical alterations in patients with Chronic Kidney Disease (CKD). This was a retrospective, observational, exploratory, and quantitative study in which the necessary information was obtained through medical record review. Quarterly biochemical tests and complete blood counts from 2023, as well as epidemiological data, were included. The patient profile from the clinic consisted of 80% males, aged 39 to 80 years, mostly of mixed ethnicity, with systemic arterial hypertension as the most common underlying condition. The study identified alterations in creatinine, potassium, calcium, parathyroid hormone, and alkaline phosphatase levels; however, hemodialysis was found to significantly reduce urea levels. Elevated levels of ferritin and transferrin saturation index indicated iron accumulation in storage sites and reduced circulating iron. Furthermore, reduced hemoglobin levels and erythrocytes with slight microcytosis and hypochromia were observed, which indicated the presence of hypoproliferative anemia. Therefore, the combination of clinical and laboratory evaluations supports diagnosis and treatment according to the degree of renal damage and is essential for reducing mortality rates.